Functional Genomics

Functional genomics is the study of gene function and interaction at a systems level, with the goal of understanding how genomic information translates into biological activity and phenotype. Unlike traditional genetics, which often focuses on single genes in isolation, functional genomics leverages high-throughput technologies and computational tools to map complex gene networks and their responses to perturbations.

At Atlas Biotech, we harness functional genomics to power target discovery, drug mechanism elucidation, and biomarker identification, enabling faster and more precise therapeutic development.

Applications in Precision Medicine

Functional genomics is transforming oncology, immunology, and rare disease research by providing context-specific gene-function maps. Key applications include:

  • Target Validation: Genome-wide CRISPR screens help identify and validate new druggable targets based on cellular dependencies4.

  • Resistance Mechanism Discovery: Functional profiling reveals pathways and mutations that confer resistance to small molecule or biologic therapies.

  • Companion Diagnostic Development: By linking genotype to drug response, functional genomics supports the development of biomarkers that guide patient selection.

Our platform integrates functional data with genomic and clinical annotations to help partners reduce risk in early-stage R&D.

Commercial Value and Differentiation

Functional genomics offers a scalable, data-rich, and hypothesis-free approach to drug discovery. For biopharmaceutical companies, it:

  • Accelerates lead prioritization and de-risking of drug candidates

  • Improves success rates by ensuring mechanism-based target engagement

  • Enables precision therapeutic strategies through patient stratification

At Atlas Biotech, we combine proprietary functional genomics workflows with expert data science and automation to deliver actionable insights across the drug development pipeline.

Deep mutational scanning

Available in both quantitative and qualitative methods, deep mutational scanning enables the direct investigation of protein variants in a complex pool.

          CRISPR screens          

Broadly and efficiently explore genome-wide loss-of-function, gain-of-function, or more nuanced readouts in any culturable cell line.

              Base editing               

Rapidly explore the impact of specific mutations on the function of a target gene or genes, made through endogenous edits directly in the genome.