Characterizing Variants of Uncertain Drug Resistance (VUDRs) Using Quantitative Measurements at Clinical ExposuresA side-by-side comparison of variant function measurements using deep mutational scanning and base editingQuantifying resistance to targeted anticancer therapies at scale with duplex sequencingMassively parallel functional assessment of label-free mutant pools is a universal approach to parametrize mechanistic models of drug resistance evolutionExcessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing
