CRISPR Screening Services
CRISPR-based functional genomics is transforming drug discovery, target validation, and biomarker identification. By enabling precise, high-throughput gene perturbation across the entire genome, CRISPR screening empowers researchers to uncover the genetic drivers of disease, identify new therapeutic targets, and predict patient responses.
At Atlas Biotech, we offer comprehensive CRISPR screening services—from experimental design through data interpretation—to accelerate your research and guide confident, data-driven decisions.
Why CRISPR Screening?
CRISPR screening provides unparalleled advantages over traditional RNAi or overexpression methods:
Precision editing – Knock out, knock down, or activate genes with single-gene specificity.
Scalable throughput – Interrogate thousands of genes in a single experiment.
Versatile applications – Applicable to diverse cell types, model systems, and phenotypic readouts.
Robust, reproducible results – Minimized off-target effects compared to earlier gene perturbation tools.
Our CRISPR Screening Capabilities
Screening Modalities
We offer both pooled and arrayed screening formats:
Pooled screens – Genome-wide or custom library delivery followed by phenotypic selection and next-generation sequencing (NGS) readout.
Arrayed screens – Individual gene perturbations in multiwell plates for high-content phenotypic analysis.
Functional Approaches
Loss-of-function – CRISPR-Cas9 knockout or CRISPR interference (CRISPRi) for gene silencing.
Gain-of-function – CRISPR activation (CRISPRa) to upregulate gene expression.
Base editing & prime editing – Introduce precise point mutations without double-strand breaks.
Readouts & Analytics
Cell viability & proliferation assays
Drug sensitivity/resistance profiling
Reporter gene activation
Multi-omic integration with RNA-seq, proteomics, and metabolomics
Advanced bioinformatics pipelines for hit calling, pathway enrichment, and network mapping
Applications in Research & Development
Our CRISPR screening services support:
Target discovery & validation – Identify genes essential for disease progression or therapeutic response.
Mechanism of action studies – Reveal pathways impacted by your drug candidate.
Synthetic lethality mapping – Find genetic vulnerabilities that can be exploited in cancer therapy.
Biomarker discovery – Link genetic perturbations to phenotypic outcomes for patient stratification.
Why Partner with Us
Customizable screening libraries – Genome-wide or highly targeted panels.
Expert assay development – Tailored protocols for your cell line or organism.
End-to-end project management – From design to data delivery.
Regulatory-grade documentation – Suitable for preclinical and translational research programs.
Get Started
CRISPR screening can be the key to unlocking breakthrough discoveries in your research. Whether you need a large-scale genome-wide screen or a focused pathway-specific study, Atlas Biotech provides the expertise, technology, and support to make it happen.
Contact us today to discuss your project needs and learn how CRISPR screening can accelerate your path to discovery.